Article
Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene.
Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 1996
Kirby S L, Cook D N, Walton W, Smithies O
Abstract excerpt
The long-term efficacy of gene therapy using bone marrow transplantation requires the engraftment of genetically altered totipotent hematopoietic stem cells (THSCs). Ex vivo expansion of corrected THSCs is one way to increase the efficiency of the procedure. Similarly, selective in vivo expansion...
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