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Article

Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells.

PloS one - 20 Dec 2010

Vento Maria Teresa, Zazzu Valeria, Loffreda Alessia, Cross Justin R, Downward Julian, Stoppelli Maria Patrizia, Iaccarino Ingram

Abstract excerpt

Increased expression of Bcl-xL in cancer has been shown to confer resistance to a broad range of apoptotic stimuli and to modulate a number of other aspects of cellular physiology, including energy metabolism, cell cycle, autophagy, mitochondrial fission/fusion and cellular adhesion. However, only few of these activities have a mechanistic explanation. Here we used Tandem Affinity purification to identify novel...

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Identifiers

PMID: 21203533
DOI: 10.1371/journal.pone.0015636
PMCID: PMC3006391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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