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Article

WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene.

The EMBO journal - 15 Jul 1999

Mayo M W, Wang C Y, Drouin S S, Madrid L V, Marshall A F, Reed J C, Weissman B E, Baldwin A S

Abstract excerpt

The Wilms' tumor suppressor gene, WT1, encodes a zinc finger transcription factor that has been demonstrated to negatively regulate several growth factor and cognate receptor genes. However, inconsistent with its tumor suppressor function, WT1 has also been demonstrated to be required to inhibit programmed cell death in vitro and in vivo. Moreover, anaplastic Wilms' tumors, which typically express wild-type WT1,...

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Identifiers

PMID: 10406804
DOI: 10.1093/emboj/18.14.3990
PMCID: PMC1171475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene.PMID 10406804Read ↗

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TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levelsSemantic proximity Read ↗

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