Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf.

doi:10.1042/bj3350241

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Article

Stimulation of gene expression in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral.GDS) and phosphatidylinositol 3-kinase in addition to Raf.

The Biochemical journal - 15 Oct 1998

Fuller S J, Finn S G, Downward J, Sugden P H

Abstract excerpt

Treatment of cultured neonatal ventricular myocytes with oncogenic Ras increases their size and stimulates the re-expression of genes which are normally restricted to the fetal stage of ventricular development, including atrial natriuretic factor (ANF) and skeletal muscle (SkM)-alpha-actin. To de...

Topics

Actins
Animals
Atrial Natriuretic Factor
Cell Size
Cells, Cultured
GTP-Binding Proteins
Gene Expression Regulation
Genes, fos
Genes, ras
Heart Ventricles
Humans
Luciferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phosphatidylinositol 3-Kinases

Proto-Oncogene Proteins c-raf

Rats

Rats, Sprague-Dawley

Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9761720
DOI: 10.1042/bj3350241
PMCID: PMC1219775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9761720-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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