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Article

Analysis of chromosomal instability in pulmonary or liver metastases and matched primary hepatocellular carcinoma after orthotopic liver transplantation.

International journal of cancer - 10 May 2003

Gross-Goupil Marine, Riou Philippe, Emile Jean-François, Saffroy Raphaël, Azoulay Daniel, Lacherade Isabelle, Receveur Aline, Piatier-Tonneau Dominique, Castaing Denis, Debuire Brigitte, Lemoine Antoinette

Abstract excerpt

To investigate the genetic mechanism of metastatic spread in hepatocellular carcinoma (HCC), we analyzed genomic changes in lung or liver metastases and the corresponding primary tumors (83 tumor samples) in 18 patients who underwent orthotopic liver transplantation. We studied the incidence of microsatellite instability (MSI) and loss of heterozygosity (LOH) involving 8 highly polymorphic microsatellite markers...

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Identifiers

PMID: 12640682
DOI: 10.1002/ijc.11017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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