Article
Microsatellite instability at selected tetranucleotide repeats is associated with p53 mutations in non-small cell lung cancer.
Cancer research - 1 May 2000
Ahrendt S A, Decker P A, Doffek K, Wang B, Xu L, Demeure M J, Jen J, Sidransky D
Abstract excerpt
Microsatellite alterations are useful clonal markers for the early detection of cancer. An increase in microsatellite instability has been observed at certain tetranucleotide repeat markers (AAAGn) in lung, head and neck, and bladder cancer. However, the genetic mechanism underlying these elevated microsatellite alterations at selected tetranucleotide repeat (EMAST) tumors is still unknown. The p53 gene plays an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
