Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Up-regulation of type II collagen gene by 17β-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor α.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2014

Maneix Laure, Servent Aurélie, Porée Benoît, Ollitrault David, Branly Thomas, Bigot Nicolas, Boujrad Noureddine, Flouriot Gilles, Demoor Magali, Boumediene Karim, Moslemi Safa, Galéra Philippe

Abstract excerpt

UNLABELLED: The existence of a link between estrogen deprivation and osteoarthritis (OA) in postmenopausal women suggests that 17β-estradiol (17β-E2) may be a modulator of cartilage homeostasis. Here, we demonstrate that 17β-E2 stimulates, via its receptor human estrogen receptor α 66 (hERα66), type II collagen expression in differentiated and dedifferentiated (reflecting the OA phenotype) articular chondrocytes....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage, Articular
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type II

Share to Estradiol

Share to Estrogen Receptor alpha

Share to SOX9 Transcription Factor

Share to Sp1 Transcription Factor

Share to Sp3 Transcription Factor

Source

Identifiers

PMID: 25081415
DOI: 10.1007/s00109-014-1195-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Up-regulation of type II collagen gene by 17β-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor α.PMID 25081415Read ↗

17β-Estradiol Induces IL-1 α Gene Expression in Rheumatoid Fibroblast-Like Synovial Cells through Estrogen Receptor α (ERα) and Augmentation of Transcriptional Activity of Sp1 by Dissociating Histone Deacetylase 2 from ERαSemantic proximity Read ↗

Sex-Specific Modulation of Gene Expression by 17beta-Estradiol in Human Meniscal Cells: Pathways to Targeted Osteoarthritis TherapiesSemantic proximity Read ↗

Expression of genes for estrogen receptors α and β in human articular chondrocytesSemantic proximity Read ↗

Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymesSemantic proximity Read ↗

Identification of SOX9 Interaction Sites in the Genome of ChondrocytesSemantic proximity Read ↗

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytesSemantic proximity Read ↗

17β-Estradiol-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes.Semantic proximity Read ↗

Brief Report: Importance of SOX8 for In Vitro Chondrogenic Differentiation of Human Mesenchymal Stromal CellsSemantic proximity Read ↗

Identification of the core element responsive to runt‐related transcription factor 2 in the promoter of human type x collagen geneSemantic proximity Read ↗

SOX9 Exerts a Bifunctional Effect on Type II Collagen Gene (COL2A1) Expression in Chondrocytes Depending on the Differentiation StateSemantic proximity Read ↗

Clinical and genomic crosstalk between glucocorticoid receptor and estrogen receptor α in endometrial cancerSemantic proximity Read ↗

Novel role of estrogen receptor-α on regulating chondrocyte phenotype and response to mechanical loading.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.