Tardive dyskinesia and debrisoquine 4-hydroxylase (CYP2D6) genotype in Japanese schizophrenics.

doi:10.1016/s0920-9964(98)00018-8

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Article

Tardive dyskinesia and debrisoquine 4-hydroxylase (CYP2D6) genotype in Japanese schizophrenics.

Schizophrenia research - 27 Jul 1998

Ohmori O, Suzuki T, Kojima H, Shinkai T, Terao T, Mita T, Abe K

Abstract excerpt

Previous studies have shown that many neuroleptics are metabolized by debrisoquine 4-hydrolase (CYP2D6), which exhibits genetic polymorphisms. In Oriental populations, poor metabolizers (PMs) with a lack of CYP2D6 activity are rare, although the CYP2D6*10 allele, which is associated with decrease...

Topics

Alleles
Antipsychotic Agents
Cytochrome P-450 CYP2D6
Dyskinesia, Drug-Induced
Female
Genotype
Humans
Japan
Male
Middle Aged
Polymorphism, Genetic
Schizophrenia

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