Article
Antipsychotic drug-induced movement disorders in schizophrenics in relation to CYP2D6 genotype.
The British journal of psychiatry : the journal of mental science - 1 Jan 1997
Armstrong M, Daly A K, Blennerhassett R, Ferrier N, Idle J R
Abstract excerpt
BACKGROUND: Approximately 5-10% of Caucasians (poor metabolisers) show impaired metabolism of at least 20 therapeutically important drugs, including a number of commonly used antipsychotic agents, because they lack the cytochrome p450 enzyme CYP2D6. The molecular basis of this defect is now well understood and simple genotyping tests using the polymerase chain reaction (PCR) have been developed. METHOD: To...
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