Article
Cytochrome P450 2D6 genotyping and association with tardive dyskinesia in Chinese schizophrenic patients.
Pharmacopsychiatry - 1 Nov 2001
Lam L C, Garcia-Barcelo M M, Ungvari G S, Tang W K, Lam V K, Kwong S L, Lau B S, Kwong P P, Waye M M, Chiu H F
Abstract excerpt
BACKGROUND: The discovery of Cytochrome P450 2D6 (CYP 2D6) polymorphism is implicated in individual differences in drug metabolism rate. Mutation with defective alleles is associated with reduced metabolism of many anti-psychotic drugs metabolized by CYP 2D6. This may contribute to the development of tardive dyskinesia (TD) in patients with prolonged exposure to anti-psychotic drugs. METHODS: In this controlled...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.