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Article

Pathway utilization in response to a site-specific DNA double-strand break in fission yeast.

The EMBO journal - 17 Mar 2003

Prudden John, Evans Joanne S, Hussey Sharon P, Deans Bryan, O'Neill Peter, Thacker John, Humphrey Tim

Abstract excerpt

We have examined the genetic requirements for efficient repair of a site-specific DNA double-strand break (DSB) in Schizosaccharomyces pombe. Tech nology was developed in which a unique DSB could be generated in a non-essential minichromosome, Ch(16), using the Saccharomyces cerevisiae HO-endonuclease and its target site, MATa. DSB repair in this context was predominantly through interchromosomal gene conversion....

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Share to Chromosomes, Fungal
Share to Deoxyribonucleases, Type II Site-Specific

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12628934
DOI: 10.1093/emboj/cdg119
PMCID: PMC151045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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