Article
Real versus virtual phenotype to guide treatment in heavily pretreated patients: 48-week follow-up of the Genotipo-Fenotipo di Resistenza (GenPheRex) trial.
Journal of acquired immune deficiency syndromes (1999) - 1 Mar 2003
Mazzotta Francesco, Lo Caputo Sergio, Torti Carlo, Tinelli Carmine, Pierotti Piera, Castelli Francesco, Lazzarin Adriano, Angarano Gioacchino, Maserati Renato, Gianotti Nicola, Ladisa Nicoletta, Quiros-Roldan Eugenia, Rinehart Alex R, Carosi Giampiero
Abstract excerpt
We compared viroimmunologic response after real phenotype (r-PHT) versus virtual phenotype (v-PHT) in patients failing highly active antiretroviral therapy (HAART). A total of 201 patients with >2 years of exposure, more than six experienced drugs, >1000 HIV RNA copies/mL, and on stable HAART for >6 months were randomized to the r-PHT or v-PHT arm. The primary end point was the proportion of HIV plasma viral load...
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