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Article

Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease.

The Journal of biological chemistry - 1 Aug 2008

Perrino Fred W, de Silva Udesh, Harvey Scott, Pryor Edward E, Cole Daniel W, Hollis Thomas

Abstract excerpt

The activity of human TREX2-catalyzed 3' --> 5'-deoxyribonuclease has been analyzed in steady-state and single turnover kinetic assays and in equilibrium DNA binding studies. These kinetic data provide evidence for cooperative DNA binding within TREX2 and for coordinated catalysis between the TREX2 active sites supporting a model for communication between the protomers of a TREX2 dimer. Mobile loops positioned...

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Source

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Identifiers

PMID: 18534978
DOI: 10.1074/jbc.M803629200
PMCID: PMC2490786

Genes

TREX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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