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Article

Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule.

The Journal of physiology - 1 May 2003

Wang Ging Kuo, Wang Sho-Ya

Abstract excerpt

Veratridine (VTD) is an alkaloid toxin found in Liliaceae plants. VTD causes persistent opening of the voltage-gated Na+ channel and reduces its single-channel conductance by 75 %. The mechanisms for these different VTD actions are unknown. Recent reports indicate that the VTD receptor aligns closely with the local anaesthetic (LA) receptor, which resides at D1S6, D3S6 and D4S6 of the Na+ channel alpha-subunit....

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Identifiers

PMID: 12626674
DOI: 10.1113/jphysiol.2002.035469
PMCID: PMC2342907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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