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Liver Cell Polyploidization: A Pivotal Role for Binuclear Hepatocytes

1 May 2003

Abstract excerpt

Polyploidy is a general physiological process indicative of terminal differentiation. During liver growth, this process generates the appearance of tetraploid (4n) and octoploid (8n) hepatocytes with one or two nuclei. The onset of polyploidy in the liver has been recognized for quite some time; however, the cellular mechanisms that govern it remain unknown. In this report, we observed the sequential appearance...

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PMID: 12626502
DOI: 10.1074/jbc.m300982200

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