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Article

Virulence of a hemB mutant displaying the phenotype of a Staphylococcus aureus small colony variant in a murine model of septic arthritis.

Microbial pathogenesis - 1 Feb 2003

Jonsson Ing-Marie, von Eiff Christof, Proctor Richard A, Peters Georg, Rydén Cecilia, Tarkowski Andrzej

Abstract excerpt

Persistence of Staphylococcus aureus during invasive infections has been associated with a small-colony variant (SCV) phenotype. SCVs are frequently auxotrophic for menadione or hemin, two compounds involved in the biosynthesis of the electron transport chain. SCVs have been shown to be more resistant to antibiotics such as aminoglycosides, grow slowly and persist intracellularly. The aim of this study was to...

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PMID: 12623275
DOI: 10.1016/s0882-4010(02)00208-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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