Article
A site-directed Staphylococcus aureus hemB mutant is a small-colony variant which persists intracellularly.
Journal of bacteriology - 1 Aug 1997
von Eiff C, Heilmann C, Proctor R A, Woltz C, Peters G, Götz F
Abstract excerpt
Although small-colony variants (SCVs) of Staphylococcus aureus have been recognized for many years, this phenotype has only recently been related to persistent and recurrent infections. Clinical S. aureus SCVs are frequently auxotrophic for menadione or hemin, two compounds involved in the biosynthesis of the electron transport chain elements menaquinone and cytochromes, respectively. While this observation as...
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