Article
Multidrug resistance modulators PSC 833 and CsA show differential capacity to induce apoptosis in lymphoid leukemia cell lines independently of their MDR phenotype.
Leukemia research - 1 May 2003
Lopes Eloisi C, Garcia Mariana, Benavides Fernando, Shen Jianjun, Conti Claudio J, Alvarez Elida, Hajos Silvia E
Abstract excerpt
Among the mechanisms that induce multidrug resistance (MDR), one of those most frequent is over-expression of a phosphoglycoprotein (Pgp) encoded in the mouse by the mdr-1 and mdr-3 genes. We have demonstrated that cyclosporin-A (CsA) as well as its analogue PSC 833 were able to revert the MDR phenotype in murine cell lines resistant to vincristine (LBR-V160) or doxorubicin (LBR-D160). The aim of this work was to...
Topics
- ATP Binding Cassette Transporter, Subfamily B
- ATP-Binding Cassette Transporters
- Animals
- Antineoplastic Agents
- Apoptosis
- Cell Cycle
- Cyclosporine
- Cyclosporins
- Doxorubicin
- Drug Resistance, Multiple