Article
Growth inhibition, cytokinesis failure and apoptosis of multidrug-resistant leukemia cells after treatment with P-glycoprotein inhibitory agents.
Leukemia - 1 May 1999
Lehne G, De Angelis P, den Boer M, Rugstad H E
Abstract excerpt
The multidrug transporter P-glycoprotein (Pgp), which is frequently overexpressed in multidrug resistant leukemia, has many proposed physiological functions including involvement in transmembraneous transport of certain growth-regulating cytokines. Therefore, we studied cell growth of three pairs of drug resistant and sensitive leukemia cell lines (KG1a, K562 and HL60) exposed to three different inhibitors of...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents
- Apoptosis
- Cyclosporins
- Daunorubicin
- Dibenzocycloheptenes
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Humans
- Leukemia
- Peptides, Cyclic
- Phenotype
- Quinolines
- Tumor Cells, Cultured