Article
Tumor necrosis factor alpha is a powerful apoptotic inducer in lymphoid leukemic cells expressing the P-170 glycoprotein.
International journal of cancer - 17 Jul 1996
Malorni W, Rainaldi G, Tritarelli E, Rivabene R, Cianfriglia M, Lehnert M, Donelli G, Peschele C, Testa U
Abstract excerpt
Multidrug resistance (MDR) is a phenomenon by which tumor cells exposed to a single anti-proliferative agent acquire resistance to other structurally and functionally unrelated drugs. The classical form of MDR is caused by a plasma-membrane protein currently named P-glycoprotein or P-170 encoded...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Apoptosis
- Cell Division
- Cycloheximide
- Drug Resistance, Multiple
- Flow Cytometry
- Fluorescent Antibody Technique
- Humans
- Leukemia, Lymphoid
- Microscopy, Fluorescence
- Phenotype
- Protein Synthesis Inhibitors
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha