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Article

Bisphosphonates induce apoptosis in CLL cells independently of MDR phenotype.

Cancer chemotherapy and pharmacology - 1 Jun 2008

Silva Karina Lani, Vasconcellos Deborah Vidal, Castro Eric Delfraro de Paula, Vasconcelos Flavia da Cunha, Bigni Ricardo, Maia Raquel Ciuvalschi

Abstract excerpt

PURPOSE: The anti-tumoral activity of bisphosphonates (BPs) has been reported in leukemia. In this study, we attempted to evaluate the apoptotic effects of the BPs pamidronate (PAM) and zoledronic acid (ZOL) in chronic lymphocytic leukemia (CLL) samples, and to correlate it with clinical parameters and multidrug resistance (MDR) phenotype (P-glycoprotein and multidrug resistance-related protein expression and/or...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple

Share to Drug Resistance, Neoplasm

Share to Flow Cytometry

Share to Genes, MDR

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

Source

Identifiers

PMID: 18335218
DOI: 10.1007/s00280-008-0710-1

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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