Article
Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease.
American journal of human genetics - 1 Apr 2003
Mirza Muddassar M, Fisher Sheila A, King Kathy, Cuthbert Andrew P, Hampe Jochen, Sanderson Jeremy, Mansfield John, Donaldson Peter, Macpherson Andrew J S, Forbes Alastair, Schreiber Stefan, Lewis Cathryn M, Mathew Christopher G
Abstract excerpt
A common haplotype spanning 250 kb in the cytokine gene cluster on chromosome 5q31 has recently been reported to be strongly associated with Crohn disease (CD) in Canadian families. We have replicated this finding by both the transmission-disequilibrium test (TDT) (P=.016) and in a case-control association study (P=.008) in a large European cohort of patients with CD, although the increase in disease risk was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.