Article
PRKCA and multiple sclerosis: association in two independent populations.
PLoS genetics - 1 Mar 2006
Saarela Janna, Kallio Suvi P, Chen Daniel, Montpetit Alexandre, Jokiaho Anne, Choi Eva, Asselta Rosanna, Bronnikov Denis, Lincoln Matthew R, Sadovnick A Dessa, Tienari Pentti J, Koivisto Keijo, Palotie Aarno, Ebers George C, Hudson Thomas J, Peltonen Leena
Abstract excerpt
Multiple sclerosis (MS) is a chronic disease of the central nervous system responsible for a large portion of neurological disabilities in young adults. Similar to what occurs in numerous complex diseases, both unknown environmental factors and genetic predisposition are required to generate MS. We ascertained a set of 63 Finnish MS families, originating from a high-risk region of the country, to identify a...
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