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Article

ERK and p38 inhibit the expression of 4E-BP1 repressor of translation through induction of Egr-1.

The Journal of biological chemistry - 23 May 2003

Rolli-Derkinderen Malvyne, Machavoine François, Baraban Jay M, Grolleau Annabelle, Beretta Laura, Dy Michel

Abstract excerpt

4E-BP1 plays a major role in translation by inhibiting cap-dependent translation initiation. Several reports have investigated the regulation of 4E-BP1 phosphorylation, which varies along with cell differentiation and upon various stimulations, but very little is known about the regulation of its expression. In a first part, we show that the expression of 4E-BP1 protein and transcript decreases in hematopoietic...

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Identifiers

PMID: 12618431
DOI: 10.1074/jbc.M211696200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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