Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wildtype Elk-1, but not a SUMOylation mutant, represses egr-1 expression in SH-SY5Y neuroblastomas.

Neuroscience letters - 23 May 2008

Demir O, Kurnaz I Aksan

Abstract excerpt

Elk-1, an ETS domain transcription factor of the TCF (ternary complex factor) subfamily, is known to be involved in the regulation of immediate-early genes such as c-fos upon mitogen activation, and thus commonly implied in cell proliferation. Early growth response-1, Egr-1, which was known to be an immediate-early gene, has recently been shown to be pro-apoptotic for SH-SY5Y neuroblastoma cells. In that respect,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Early Growth Response Protein 1
Share to ets-Domain Protein Elk-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, fos

Share to Mitogen-Activated Protein Kinases

Share to Neuroblastoma

Share to Serine

Share to Small Ubiquitin-Related Modifier Proteins

Source

Identifiers

PMID: 18434015
DOI: 10.1016/j.neulet.2008.03.064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wildtype Elk-1, but not a SUMOylation mutant, represses egr-1 expression in SH-SY5Y neuroblastomas.PMID 18434015Read ↗

Opposing roles of Elk-1 and its brain-specific isoform, short Elk-1, in nerve growth factor-induced PC12 differentiation.Semantic proximity Read ↗

Egr‐1 is activated by 17β‐estradiol in MCF‐7 cells by mitogen‐activated protein kinase‐dependent phosphorylation of ELK‐1Semantic proximity Read ↗

Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death.Semantic proximity Read ↗

Decreased expression of the candidate tumor suppressor gene ING1 is associated with poor prognosis in advanced neuroblastomas.Semantic proximity Read ↗

Induction of the Early Growth Response 1 Gene by Epstein-Barr Virus Lytic Transactivator ZtaSemantic proximity Read ↗

Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cellsSemantic proximity Read ↗

Biological activity of RE-1 silencing transcription factor (REST) towards distinct transcriptional activators.Semantic proximity Read ↗

Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast.Semantic proximity Read ↗

Activation of Elk-1 participates as a neuroprotective compensatory mechanism in models of Huntington's disease.Semantic proximity Read ↗

Inhibited neurogenesis in JNK1-deficient embryonic stem cells.Semantic proximity Read ↗

Ets-2 repressor factor recruits histone deacetylase to silence human cytomegalovirus immediate-early gene expression in non-permissive cellsSemantic proximity Read ↗

FoxG1 promotes the survival of postmitotic neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.