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Article

Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region".

Genomics - 15 Dec 1996

Song W J, Sternberg L R, Kasten-Sportès C, Keuren M L, Chung S H, Slack A C, Miller D E, Glover T W, Chiang P W, Lou L, Kurnit D M

Abstract excerpt

The presence of an extra copy of human chromosome 21 (trisomy 21), especially region 21q22.2, causes many phenotypes in Down syndrome, including mental retardation. To study genes potentially responsible for some of these phenotypes, we cloned a human candidate gene (DYRK) from 21q22.2 and its murine counterpart (Dyrk) that are homologous to the Drosophila minibrain (mnb) gene required for neurogenesis and to the...

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PMID: 8975710
DOI: 10.1006/geno.1996.0636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region".PMID 8975710Read ↗

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