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Article

The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians.

Human genetics - 1 Apr 2003

Vozarova Barbora, Fernández-Real José-Manuel, Knowler William C, Gallart Lluis, Hanson Robert L, Gruber Jonathan D, Ricart Wilfredo, Vendrell Joan, Richart Cristóbal, Tataranni P Antonio, Wolford Johanna K

Abstract excerpt

Chronic low-grade activation of the immune system may play a role in the pathogenesis of type-2 diabetes mellitus (T2DM). Interleukin-6 (IL6), a powerful inducer of hepatic acute phase response, has been implicated in the etiology of insulin resistance and T2DM. Recently, an IL6 promoter polymorphism (G/C) at position -174 was found to be associated with measures of insulin sensitivity. Because we have previously...

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PMID: 12589429
DOI: 10.1007/s00439-003-0912-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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