Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5.

The Biochemical journal - 1 Jun 2003

Kotera Jun, Grimes Kennard A, Corbin Jackie D, Francis Sharron H

Abstract excerpt

The physiological effects of cGMP are largely determined by the activities of intracellular receptors, including cGMP-dependent protein kinase (PKG) and cGMP-binding cyclic nucleotide phosphodiesterases (PDEs), and the distribution of cGMP among these receptors dictates activity of the signalling pathway. In the present study, the effects of PKG-Ialpha or PKG-Ibeta on the rate of cGMP hydrolysis by the isolated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3',5'-Cyclic-GMP Phosphodiesterases
Share to Allosteric Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic GMP

Share to Cyclic GMP-Dependent Protein Kinases

Share to Dimerization

Share to Enzyme Activation

Share to Hydrolysis

Share to Phosphoric Diester Hydrolases

Source

Open in PubMed Open full text

Identifiers

PMID: 12617722
DOI: 10.1042/BJ20030107
PMCID: PMC1223414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5.PMID 12617722Read ↗

Distinguishing the roles of the two different cGMP-binding sites for modulating phosphorylation of exogenous substrate (heterophosphorylation) and autophosphorylation of cGMP-dependent protein kinase.Semantic proximity Read ↗

Signalling by cGMP-dependent protein kinases.Semantic proximity Read ↗

Overview of PDEs and their regulation.Semantic proximity Read ↗

Inhibition of Galphaq-dependent PLC-beta1 activity by PKG and PKA is mediated by phosphorylation of RGS4 and GRK2.Semantic proximity Read ↗

Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease.Semantic proximity Read ↗

Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoA.Semantic proximity Read ↗

Phosphodiesterase type 1 regulates adenosine 2A receptor-associated cAMP signaling at the plasma membrane to increase myocardial contractilitySemantic proximity Read ↗

Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.Semantic proximity Read ↗

Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism.Semantic proximity Read ↗

Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration.Semantic proximity Read ↗

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.Semantic proximity Read ↗

Differential expression of multidrug resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.