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Article

Differential expression of multidrug resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle.

American journal of physiology. Gastrointestinal and liver physiology - 15 Aug 2013

Al-Shboul Othman, Mahavadi Sunila, Sriwai Wimolpak, Grider John R, Murthy Karnam S

Abstract excerpt

Previous studies have identified differences in the expression of proteins that regulate myosin light chain phosphorylation and contraction in tonic and phasic smooth muscle. cGMP plays a critical role in smooth muscle relaxation and is important for optimal function of phasic and tonic smooth muscle. The intracellular cGMP levels are regulated by its hydrolysis via phosphodiesterase 5 (PDE5) and efflux via novel...

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Identifiers

PMID: 23764893
DOI: 10.1152/ajpgi.00457.2012
PMCID: PMC3891211

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