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Article

Effects of IL-6 variants in multiple myeloma: growth inhibition and induction of apoptosis in primary cells.

Leukemia & lymphoma - 1 Dec 2002

Petrucci Maria Teresa, Ricciardi Maria Rosaria, Gregorj Chiara, Ciapponi Laura, Savino Rocco, Ciliberto Gennaro, Tafuri Agostino

Abstract excerpt

Interleukin-6 (IL-6) plays a pathogenetic role in B-cell malignancies and is a growth factor for multiple myeloma (MM) cells. Elevated serum IL-6 levels and a higher proliferative activity of bone marrow plasma cells are poor prognostic factors in MM patients. In addition to clinical trials with anti-IL-6 monoclonal antibodies, an alternative therapeutic approach based on the use of IL-6 receptor (R)...

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Source

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PMID: 12613526
DOI: 10.1080/1042819021000040224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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