Article
Interleukin-6-induced inhibition of multiple myeloma cell apoptosis: support for the hypothesis that protection is mediated via inhibition of the JNK/SAPK pathway.
Blood - 1 Jul 1998
Xu F H, Sharma S, Gardner A, Tu Y, Raitano A, Sawyers C, Lichtenstein A
Abstract excerpt
The mechanism by which interleukin-6 (IL-6) protects multiple myeloma (MM) plasma cells from apoptosis induced by anti-fas antibodies and dexamethasone was studied. Anti-apoptotic concentrations of IL-6 had no effect on cell-cycle distribution or activation of RAF-1 or ERK in dexamethasone- or an...
Topics
- Apoptosis
- Humans
- Interleukin-6
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase 4
- Mitogen-Activated Protein Kinase Kinases
- Multiple Myeloma
- Mutation
- Protein Kinases
- Proto-Oncogene Proteins c-jun
- Signal Transduction
- Tumor Cells, Cultured