Article
Gene-expression profiles in hereditary breast cancer.
Advances in anatomic pathology - 1 Jan 2002
Chinnaiyan Arul M, Rubin Mark A
Abstract excerpt
DNA microarray technology is revolutionizing the way fundamental biologic questions are addressed in the postgenomic era. In this study by Hedenfalk et al., the authors attempted to identify discrete gene expression profiles for patients with known hereditary breast cancers caused by mutations in BRCA1 and BRCA2, both of which increase the lifetime risk of developing breast cancer. The genome-wide perspective...
Topics
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- DNA, Neoplasm
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Genes, BRCA1
- Genes, BRCA2
- Humans
- Mutation
- Neoplasm Proteins
- Oligonucleotide Array Sequence Analysis