Article
A non-BRCA1/2 hereditary breast cancer sub-group defined by aCGH profiling of genetically related patients.
Breast cancer research and treatment - 1 Nov 2011
Didraga M A, van Beers E H, Joosse S A, Brandwijk K I M, Oldenburg R A, Wessels L F A, Hogervorst F B L, Ligtenberg M J, Hoogerbrugge N, Verhoef S, Devilee P, Nederlof P M
Abstract excerpt
Germline mutations in BRCA1 and BRCA2 explain approximately 25% of all familial breast cancers. Despite intense efforts to find additional high-risk breast cancer genes (BRCAx) using linkage analysis, none have been reported thus far. Here we explore the hypothesis that BRCAx breast tumors from genetically related patients share a somatic genetic etiology that might be revealed by array comparative genomic...
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