Article
Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1.
Cancer research - 15 Dec 1996
Hsu S C, Volpert O V, Steck P A, Mikkelsen T, Polverini P J, Rao S, Chou P, Bouck N P
Abstract excerpt
Glioblastoma multiforme is distinguished from its less malignant astrocytoma precursors by intense angiogenesis and frequent loss of tumor suppressor genes on chromosome 10. Here we link these traits by showing that when a wild-type chromosome 10 was returned to any of three human glioblastoma cell lines U251, U87, or LG11, they lost their ability to form tumors in nude mice and switched to an antiangiogenic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.