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Article

Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells.

Diabetes - 1 Mar 2003

Greening James E, Tree Timothy I M, Kotowicz Karolena T, van Halteren Astrid G, Roep Bart O, Klein Nigel J, Peakman Mark

Abstract excerpt

Type 1 diabetes is characterized by T-cell infiltration of the islets of Langerhans and abundant HLA class II molecule expression on islet endothelial cells (ECs). The specificity of infiltrating T-cells for islet autoantigens has been amply demonstrated in animal models, and is implicit in human diabetes, but the processes regulating endothelial transmigration of islet autoantigen-specific T-cells into islets...

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Identifiers

PMID: 12606513
DOI: 10.2337/diabetes.52.3.717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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