Article
Endothelial cell-binding properties of lymphocytes infiltrated into human diabetic pancreas. Implications for pathogenesis of IDDM.
Diabetes - 1 Nov 1993
Hänninen A, Salmi M, Simell O, Jalkanen S
Abstract excerpt
In IDDM, mononuclear cells accumulate in the islets of Langerhans and destroy insulin-producing beta-cells. To study the mechanisms that control extravasation of circulating mononuclear cells into the pancreas, we examined the phenotype of vascular endothelium of the pancreas, propagated a T-cell...
Topics
- Cell Adhesion
- Cell Communication
- Cell Division
- Cell Movement
- Child
- Diabetes Mellitus, Type 1
- Endothelium, Vascular
- Female
- Fluorescent Antibody Technique
- Humans
- Immunohistochemistry
- Pancreas
- Phenotype
- T-Lymphocytes