Immunomodulatory endothelial cells contribute to T-cell recruitment and activation via antigen presentation on MHC II.

doi:10.1093/cvr/cvag137

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Article

Immunomodulatory endothelial cells contribute to T-cell recruitment and activation via antigen presentation on MHC II.

Cardiovascular research - 26 Aug 2026

Cartura Matteo, Aliraj Blerina, Szymański Witold, Park Christian, Ferrario Giulio, Rezende Flávia, Güven Beyza, Bleckwehl Tore, Sachs Nadja, Mägdefessel Lars, Dimmeler Stefanie, Müller Oliver J, Jo Hanjoong, Offermanns Stefan, Hayat Sikander, Brandes Ralf P, Münch Christian, Graumann Johannes, Weigert Andreas, Fleming Ingrid, Siragusa Mauro

Abstract excerpt

AIMS: A subset of endothelial cells referred to as immunomodulatory endothelial cells (IMEC) has been proposed to regulate T-cell responses in atherosclerosis and after myocardial infarction. Here, we studied the inflammation-induced emergence of IMEC and characterized their crosstalk with T cells. METHODS AND RESULTS: An in vitro model to study IMEC was characterized using flow cytometry and proteomics....

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