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Article

Pig cells that lack the gene for α1-3 galactosyltransferase express low levels of the gal antigen

27 Feb 2003

Abstract excerpt

BACKGROUND: The major antigen recognized on pig tissue by primate antibodies is a terminal galalpha1-3gal carbohydrate structure (gal antigen) present on glycolipids and glycoproteins. The production of animals from somatic cells allows for the inactivation of specific genes. It is anticipated that the complete inactivation of the gene encoding alpha1-3 galactosyltransferase, the enzyme that synthesizes the...

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PMID: 12605105
DOI: 10.1097/01.tp.0000053615.98201.77

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