Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

α1,3Galactosyltransferase knockout pigs produce the natural anti‐Gal antibody and simulate the evolutionary appearance of this antibody in primates

22 Aug 2013

Abstract excerpt

BACKGROUND: Anti-Gal is the most abundant natural antibody in humans and Old World primates (apes and Old World monkeys). Its ligand, the α-gal epitope (Galα1-3Galβ1-4GlcNAc-R), is abundant in nonprimate mammals, prosimians and New World monkeys whereas it is absent in humans and Old World primates as a result of inactivation of the α1,3galactosyltransferase (α1,3GT) gene in ancestral Old World primates, as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology
Share to Xenotransplantation and immune response

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23968556
DOI: 10.1111/xen.12051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

α1,3Galactosyltransferase knockout pigs produce the natural anti‐Gal antibody and simulate the evolutionary appearance of this antibody in primatesPMID 23968556Read ↗

Characteristics of α-Gal epitope, anti-Gal antibody, α1,3 galactosyltransferase and its clinical exploitation (Review)Semantic proximity Read ↗

An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native PigsSemantic proximity Read ↗

Polymorphism in the human anti-pig natural antibody repertoire: implications for antigen-specific immunoadsorption.Semantic proximity Read ↗

Pig cells that lack the gene for α1-3 galactosyltransferase express low levels of the gal antigenSemantic proximity Read ↗

Paleo‐immunology of human anti‐carbohydrate antibodies preventing primate extinctionsSemantic proximity Read ↗

What Have We Learned From In Vitro Studies About Pig-to-primate Organ Transplantation?Semantic proximity Read ↗

The desirable donor pig to eliminate all xenoreactive antigensSemantic proximity Read ↗

Production of alpha 1,3-galactosyltransferase-deficient pigs.Semantic proximity Read ↗

Antigenicity of tissues and organs from GGTA1/CMAH/β4GalNT2 triple gene knockout pigsSemantic proximity Read ↗

Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)Semantic proximity Read ↗

Unexpected anti-alpha GalNAc antibodies in alpha-galactosyl transferase-deficient mice: complex relationship between genotype and the natural antibody repertoire.Semantic proximity Read ↗

α1,3-Galactosyltransferase Deficiency in Germ-Free Miniature Pigs Increases N -Glycolylneuraminic Acids As the Xenoantigenic Determinant in Pig–Human XenotransplantationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.