Article
Two NOTCH4 polymorphisms and their relation to schizophrenia susceptibility and different personality traits.
Psychiatric genetics - 1 Mar 2003
Carmine Andrea, Chheda Milan G, Jönsson Erik G, Sedvall Göran C, Farde Lars, Gustavsson J Petter, Bergman Hans, Anvret Maria, Buervenich Silvia, Olson Lars
Abstract excerpt
BACKGROUND: Recently, linkage disequilibrium mapping of the major histocompatibility complex region on the short arm of human chromosome 6 suggested that the NOTCH4 locus is highly associated with schizophrenia. OBJECTIVES AND METHODS: We analysed two polymorphisms in this gene in Swedish schizophrenic patients ( =74) and control subjects ( =135). The NOTCH4 variants were also analysed in schizophrenic patients...
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