Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.

Antimicrobial agents and chemotherapy - 1 Mar 2007

El'Garch Farid, Jeannot Katy, Hocquet Didier, Llanes-Barakat Catherine, Plésiat Patrick

Abstract excerpt

Screening of a Tn5-Hg insertional library (12,000 clones) constructed in wild-type Pseudomonas aeruginosa strain PAO1 identified four genes (namely, galU, nuoG, mexZ, and rplY) whose disruption individually led to increased resistance to aminoglycosides (means of twofold). Inactivation of these genes was associated with (i) impaired outer membrane uptake, (ii) reduced active transport, (iii) increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminoglycosides
Share to DNA Transposable Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Gene Silencing

Share to Genes, Bacterial

Share to Microbial Sensitivity Tests

Share to Mutagenesis, Insertional

Share to Pseudomonas aeruginosa

Source

Open in PubMed Open full text

Identifiers

PMID: 17194835
DOI: 10.1128/AAC.00704-06
PMCID: PMC1803147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.PMID 17194835Read ↗

Multiple Mutations Lead to MexXY-OprM-Dependent Aminoglycoside Resistance in Clinical Strains of Pseudomonas aeruginosaSemantic proximity Read ↗

Mutational activation of the AmgRS two-component system in aminoglycoside-resistant Pseudomonas aeruginosa.Semantic proximity Read ↗

A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and β-lactams in Pseudomonas aeruginosa.Semantic proximity Read ↗

Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation.Semantic proximity Read ↗

Targeting a bacterial stress response to enhance antibiotic action.Semantic proximity Read ↗

MexXY-OprM Efflux Pump Is Required for Antagonism of Aminoglycosides by Divalent Cations in Pseudomonas aeruginosaSemantic proximity Read ↗

Aminoglycoside efflux in Pseudomonas aeruginosa: involvement of novel outer membrane proteins.Semantic proximity Read ↗

Transcriptional and Mutational Profiling of an Aminoglycoside-Resistant Pseudomonas aeruginosa Small-Colony Variant.Semantic proximity Read ↗

Novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa.Semantic proximity Read ↗

Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component SystemSemantic proximity Read ↗

Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

Functional interplay between RND efflux pumps and GacS in Pseudomonas aeruginosaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.