Article
Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol.
Circulation - 10 Sept 2002
deLemos Andrew S, Wolfe Megan L, Long Christopher J, Sivapackianathan Rasheeta, Rader Daniel J
Abstract excerpt
BACKGROUND: Elevated high-density lipoprotein cholesterol (HDL-C) is associated with reduced risk of cardiovascular disease, and variation in HDL-C levels has been shown to be approximately 50% heritable. Overexpression of endothelial lipase (EL), a member of the lipoprotein lipase gene family, markedly reduces HDL-C levels in mouse models. We hypothesized that genetic variation in EL might be associated with...
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