Article
Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 1996
Müllbacher A, Ebnet K, Blanden R V, Hla R T, Stehle T, Museteanu C, Simon M M
Abstract excerpt
Cytolytic lymphocytes are of cardinal importance in the recovery from primary viral infections. Both natural killer cells and cytolytic T cells mediate at least part of their effector function by target cell lysis and DNA fragmentation. Two proteins, perforin and granzyme B, contained within the cytoplasmic granules of these cytolytic effector cells have been shown to be directly involved in these processes. A...
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