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Article

Exploring the potential of the monobody scaffold: effects of loop elongation on the stability of a fibronectin type III domain.

Protein engineering - 1 Dec 2002

Batori Vincent, Koide Akiko, Koide Shohei

Abstract excerpt

The tenth fibronectin type III domain of human fibronectin (FNfn10) is a small, monomeric beta-sandwich protein, similar to the immunoglobulins. We have developed small antibody mimics, 'monobodies', using FNfn10 as a scaffold. We initially altered two loops of FNfn10 that are structurally equivalent to two of the hypervariable loops of the immunoglobulin domain. In order to assess the possibility of utilizing...

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PMID: 12601141
DOI: 10.1093/protein/15.12.1015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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