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Article

Intrauterine pulmonary hypertension impairs angiogenesis in vitro: role of vascular endothelial growth factor nitric oxide signaling.

American journal of respiratory and critical care medicine - 1 Dec 2007

Gien Jason, Seedorf Gregory J, Balasubramaniam Vivek, Markham Neil, Abman Steven H

Abstract excerpt

RATIONALE: Mechanisms that impair angiogenesis in neonatal persistent pulmonary hypertension (PPHN) are poorly understood. OBJECTIVES: To determine if PPHN alters fetal pulmonary artery endothelial cell (PAEC) phenotype and impairs growth and angiogenesis in vitro, and if altered vascular endothelial growth factor-nitric oxide (VEGF-NO) signaling contributes to this abnormal phenotype. METHODS: Proximal PAECs...

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Share to Endothelium, Vascular
Share to Fetal Development

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fetal Diseases

Share to Hypertension, Pulmonary

Share to Neovascularization, Physiologic

Share to Nitric Oxide

Share to Nitric Oxide Synthase

Share to Pulmonary Artery

Source

Open in PubMed Open full text

Identifiers

PMID: 17823355
DOI: 10.1164/rccm.200705-750OC
PMCID: PMC2176095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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