Article
Lack of EC-SOD worsens alveolar and vascular development in a neonatal mouse model of bleomycin-induced bronchopulmonary dysplasia and pulmonary hypertension.
Pediatric research - 1 Dec 2015
Delaney Cassidy, Wright Rachel H, Tang Jen-Ruey, Woods Crystal, Villegas Leah, Sherlock Laurie, Savani Rashmin C, Abman Steven H, Nozik-Grayck Eva
Abstract excerpt
BACKGROUND: Pulmonary hypertension (PH) worsens clinical outcomes in former preterm infants with bronchopulmonary dysplasia (BPD). Oxidant stress disrupts alveolar and vascular development in models of BPD. Bleomycin causes oxidative stress and induces BPD and PAH in neonatal rats. Disruption in the vascular endothelial growth factor (VEGF) and nitric oxide signaling pathways contributes to BPD. We hypothesized...
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