Article
Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
Molecular endocrinology (Baltimore, Md.) - 1 May 2003
Friedrichsen Birgitte N, Richter Henrijette E, Hansen Johnny A, Rhodes Christopher J, Nielsen Jens H, Billestrup Nils, Møldrup Annette
Abstract excerpt
Signal transducer and activator of transcription 5 (STAT5) activation plays a central role in GH- and prolactin-mediated signal transduction in the pancreatic beta-cells. In previous experiments we demonstrated that STAT5 activation is necessary for human (h)GH-stimulated proliferation of INS-1 cells and hGH-induced increase of mRNA-levels of the cell cycle regulator cyclin D2. In this study we have further...
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