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Article

The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression.

Genome research - 1 Jun 2009

Pittman Alan M, Naranjo Silvia, Webb Emily, Broderick Peter, Lips Esther H, van Wezel Tom, Morreau Hans, Sullivan Kate, Fielding Sarah, Twiss Philip, Vijayakrishnan Jayaram, Casares Fernando, Qureshi Mobshra, Gómez-Skarmeta José Luis, Houlston Richard S

Abstract excerpt

Recent genome-wide scans for colorectal cancer (CRC) have revealed the SMAD7 (mothers against decapentaplegic homolog 7) gene as a locus associated with a modest, but highly significant increase in CRC risk. To identify the causal basis of the association between 18q21 variation and CRC, we reseq...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19395656
DOI: 10.1101/gr.092668.109
PMCID: PMC2694486

Genes

SMAD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19395656-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression.PMID 19395656Read ↗

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