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Article

Defects in virion production caused by mutations affecting the C-terminal portion of the Moloney murine leukemia virus capsid protein.

Journal of virology - 1 Mar 2003

Wang Margaret Q, Goff Stephen P

Abstract excerpt

The capsid (CA) domain of the Moloney murine leukemia virus (Mo-MuLV) Gag protein has a unique carboxy terminus with a highly charged arginine-rich sequence. Mutant viruses harboring arginine-to-alanine mutations affecting this region of CA displayed significant defects in virion release, and the few viral particles produced were noninfectious. The interaction between the mutant Gag precursors was affected, as...

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Identifiers

PMID: 12584360
DOI: 10.1128/jvi.77.5.3339-3344.2003
PMCID: PMC149736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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