Article
Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice.
Cancer research - 15 Dec 2004
Sieber Oliver M, Howarth Kimberley M, Thirlwell Christina, Rowan Andrew, Mandir Nikki, Goodlad Robert A, Gilkar Ashfaq, Spencer-Dene Bradley, Stamp Gordon, Johnson Victoria, Silver Andrew, Yang Hanjing, Miller Jeffrey H, Ilyas Mohammad, Tomlinson Ian P M
Abstract excerpt
Monoallelic APC and biallelic MYH (homolog of Escherichia coli mutY) germ-line mutations are independently associated with a strong predisposition to colorectal adenomas and carcinoma in humans. Whereas mice heterozygous for mutant Apc develop intestinal tumors, mice homozygous for mutant Myh do not show increased tumor susceptibility. We analyzed the phenotype of Apc(Min/+)/Myh(-/-) mice and found that they...
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